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Forschungsbereich: Tumorbiologie, Immunologie, Signaltransduktion, Extrazellul\u00e4re Vesikel, Nanomaterialien<\/o:p><\/i><\/p>\n

Der Forschungsschwerpunkt von Dr. Irina Kube-Golovin umfasst die Tumorbiologie und Immunologie mit besonderem Fokus auf die Signaltransduktionsmechanismen von CEACAMs (Carcinoembryonic Antigen-related Cell Adhesion Molecules<\/i>). Diese Familie von Zelladh\u00e4sionsmolek\u00fclen spielt eine zentrale Rolle in biologischen Prozessen wie Zellkommunikation, Immunmodulation und Tumorentwicklung. CEACAMs befinden sich vor allem auf der Oberfl\u00e4che von Leukozyten sowie auf Epithel- und Endothelzellen. Durch ihre Interaktionen regulieren sie die Zellkommunikation und die Signaltransduktion in verschiedenen biologischen Kontexten. Dr. Kube-Golovin fokussiert sich insbesondere auf die Rolle von CEACAMs in der Tumorentstehung und -progression. Spezifische CEACAMs sind dabei als potenzielle Biomarker und therapeutische Targets von Interesse, da sie aktiv an der Tumorbildung und -ausbreitung beteiligt ist. Ziel der Forschung ist es, die CEACAM-vermittelten Signalwege besser zu verstehen und deren Einfluss auf Tumorentwicklung sowie Immunantwort zu entschl\u00fcsseln, um neue, gezielte therapeutische Ans\u00e4tze zu entwickeln.<\/o:p><\/p>\n

Zus\u00e4tzlich widmet sich Dr. Kube-Golovin der Forschung zu extrazellul\u00e4ren Vesikeln (EVs) und den therapeutischen Einsatzm\u00f6glichkeiten von Nanomaterialien. Extrazellul\u00e4re Vesikel sind entscheidend f\u00fcr den interzellul\u00e4ren Informationsaustausch und die Modulation von Immunantworten, weshalb sie eine vielversprechende Zielstruktur in der Tumorforschung darstellen. Zudem untersucht Dr. Kube-Golovin den Einsatz von 2D Nanomaterialien (MXenes), um gezielt auf CEACAMs und andere Tumormarker einzuwirken und Tumorzellen selektiv zu zerst\u00f6ren.<\/o:p><\/p>\n

Die interdisziplin\u00e4re Forschung vereint Ans\u00e4tze aus Zellbiologie, Molekularbiologie, Immunologie und Materialwissenschaften und tr\u00e4gt dazu bei, neue Strategien zur Bek\u00e4mpfung von Tumorerkrankungen zu entwickeln. Ein zentraler Bestandteil sind eigenst\u00e4ndig entwickelte molekulare Werkzeuge, wie zum Beispiel spezifische Antik\u00f6rper und rekombinante Proteine, die es erm\u00f6glichen, pr\u00e4zise Wechselwirkungen auf molekularer Ebene zu untersuchen. Dar\u00fcber hinaus kommen verschiedene Zell- und Mausmodelle zum Einsatz, die als wichtige Plattformen dienen, um die in-vitro<\/i> gewonnenen Ergebnisse auf die Komplexit\u00e4t eines ganzen Organismus zu \u00fcbertragen und zu validieren.<\/o:p><\/p>\n

Dr. Kube-Golovin betreut und bietet Bachelor-, Master- sowie Doktorarbeiten f\u00fcr naturwissenschaftliche und medizinische Studierende an. Die Beteiligung an EU- \/ DFG-gef\u00f6rderten Projekten und Kooperationen mit nationalen sowie internationalen Partnern bieten interdisziplin\u00e4re und abwechslungsreiche M\u00f6glichkeiten f\u00fcr wissenschaftliche Zusammenarbeit, den Austausch von Wissen und die Weiterentwicklung innovativer Forschungsans\u00e4tze.<\/o:p><\/p>\n

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Research Focus: Tumor Biology, Immunology, Signal Transduction, Extracellular Vesicles, Nanomaterials<\/o:p><\/i><\/p>\n

Dr. Irina Kube-Golovin’s research focus includes tumor biology and immunology, with a particular emphasis on the signal transduction mechanisms of CEACAMs (Carcinoembryonic Antigen-related Cell Adhesion Molecules). This family of cell adhesion molecules plays a key role in biological processes such as cell communication, immune response, and tumor development. CEACAMs are primarily expressed on the surface of leukocytes as well as on epithelial and endothelial cells. Through their interactions, they regulate cell communication and signal transduction in various biological contexts. Dr. Kube-Golovin focuses on the role of CEACAMs in tumor formation and progression. Specific CEACAMs are of particular interest as potential biomarkers and therapeutic targets, as they are actively involved in tumor development, progression and spread. The research aims to gain a deeper understanding of CEACAM-mediated signaling pathways and their effects on tumor development and immune response, with the goal of developing new, targeted therapeutic strategies.<\/o:p><\/p>\n

In addition, Dr. Kube-Golovin focuses on the research of extracellular vesicles (EVs) and the therapeutic potential of nanomaterials. EVs are crucial for intercellular communication and modulation of immune responses, making them a promising target in cancer research. Furthermore, Dr. Kube-Golovin investigates the use of 2D nanomaterials (MXenes) to selectively target CEACAMs and other tumor markers, aiming to selectively destroy tumor cells.<\/o:p><\/p>\n

Interdisciplinary research combines approaches from cell biology, molecular biology, immunology, and materials science to develop new strategies for combating cancer. A key component of this research is the use of self-developed molecular tools, such as specific antibodies and recombinant proteins, which enable precise investigation of molecular interactions. In addition, various cell and mouse models are employed as important platforms to transfer and validate in vitro findings within the complexity of a whole organism.<\/o:p><\/p>\n

Dr. Kube-Golovin supervises and offers Bachelor’s, Master’s, and doctoral theses for students in the natural sciences and medicine. Participation in EU- \/ DFG-funded projects and collaborations with national and international partners provides interdisciplinary and diverse opportunities for scientific cooperation, knowledge exchange, and the further development of innovative research approaches.<\/o:p><\/p>\n

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Awards:<\/u><\/p>\n

–\u00a0 Singer-Award<\/i><\/b> for research excellence in the CEACAM field, 31st international CEACAM Symposium in New York City, 10\/2023<\/span><\/p>\n

–\u00a0\u00a0<\/span>Karl-Oberdisse-Preis<\/i> im Rahmen der 26. Jahrestagung der Nordrhein-Westf\u00e4lischen Gesellschaft f\u00fcr Endokrinologie und Diabetologie, 01\/2021<\/font><\/p>\n

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